applications and references

VYOO has been applied and verified in collaboration with leading international experts through investigator-initiated studies and a growing list of European centers are using VYOO as a routine clinical test.

Sepsis Diagnostics

Whole blood samples

Application Study: VYOO vs. Gold Standard Blood Culture

The purpose of this study, performed during product development, was to determine whether a molecular diagnostic approach using VYOO could offer a faster, more sensitive solution for detection of bacterial and fungal infections and antibiotic resistance as compared to conventional ‘gold standard' blood culture techniques.

Download VYOO Sepsis Study

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Reference literature

Truncated human cytidylate-phosphate-deoxyguanylate-binding protein for improved NAT-based detection of bacterial species in human samples.
Sachse S, Straube E, Lehmann M, Bauer M, Russwurm S, Schmidt KH., Journal of Clinical Microbiology, 2009
Paper on the specific enrichment of pathogen DNA incorporated in VYOO. Read the abstract and get the paper on pubmed online.

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New Approaches in Fungal DNA Preparation from Whole Blood and Subsequent Pathogen Detection Via Multiplex PCR 
Schmitz RPH, Eck R, Lehmann M, Molecular Identification of Fungi, Springer, 2010

Multiplex PCR vs. Blood Culture: Towards a New Gold Standard in Sepsis Diagnostics
Sachse S, Lehmann M, Schmitz R, Reinhart K, Straube E

Performance of a PCR based assay for pathogen detection in critically ill patients
Bloos F, Kortgen A, Sachse S, Lehmann M, Straube E, Reinhart K, Bauer M

Clinical relevance of fungal DNAemia detected by multiplex PCR in septic patients
Kortgen A, Bloos F, Sachse S, Lehmann M, Straube E, Reinhart K, Bauer M 

Applied Sepsis Diagnostics: Gold Standard Blood Culture vs. NAT-based Pathogen Detection
Sachse S, Lehmann M, Schmitz R, Russwurm S, Schmidt KH, Reinhart K, Straube E

Detection of bacterial DNA in Platelet Concentrates (Apharese Products) and whole Blood using a uniqque Sample Preparation Tool and qPCR
Barz D, Sachse S, Lehmann M, Lorenzen T, Straube E: Poster at the DGTI Congress, Sep 18-22, Friedrichshafen, Germany

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Septic Arthritis

Synovial fluid samples

Septic arthritis is a critical condition causing high morbidity and mortality. It is induced by microbial infections which are likely to occur in case of joint diseases and joint replacements.

Reference Center and sender laboratory for joint infection testing:

MPT molecular pathology Trier »

Application Study: VYOO detects joint infections

The focus of this study is to verify whether the multiplex PCR test VYOO is suitable and sensitive enough to reliably detect infections of the synovial fluid and deliver clinically meaningful data.

Download VYOO Septic Arthritis Study
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Reference Literature

Applications of molecular pathology in the diagnosis of joint Infections                     Kriegsmann J, Hopf T, Jacobs D, Arens N, Krenn V, Schmitt-Wiedhoff R, Kriegsmann M, Heisel C, Biehl C, Thabe H, Schmitz RP, Lehmann M, Otto M., Der Orthopäde, 2009
Early diagnosis of joint infections with VYOO to prevent septic arthritis. Read the abstract and get the paper on pubmed online (German article).

Molecular diagnostics of synovial fluid infection
Kriegsmann J, Thabe H, Hopf T, Jacobs D, Schmitz R, Lehmann M, Otto M

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Cirrhosis of the liver

Ascitic fluid samples

Spontaneous bacterial peritonitis (SBP) is a life-threatening complication of patients with ascites and cirrhosis of the liver. Bacterial infections of the ascitic fluid can be identified with VYOO as the study shows.

Application Study: VYOO detects infections in ascites

The focus of this study is to verify whether VYOO is suitable, fast, and sensitive enough to reliably detect bacterial infections of the ascitic fl uid and deliver clinically meaningful data.

VYOO Cirrhosis Study
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Reference Literature

Detection of ascitic fluid bacterial DNA by multiplex PCR for diagnosis of spontaneous bacterial peritonitis and prediction of short-term mortality.
Bruns T, Sachse S, Straube E, Assefa S, Herrmann A, Lehmann M, Stallmach A, Liver International, 2009
Read the abstract and get the paper on pubmed online.

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VYOO is approved for diagnostic and research use within Europe. VYOO provides solely qualitative diagnostic information. The relevance of this information to diagnosis of infection and the selection of a directed anti-infective therapy must be evaluated by a clinician together with other clinical and diagnostic findings. VYOO is for research use only in USA.